The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro

Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma.

Vera M. Keatings, Paul Collins, Diane Scott et al. · American Journal of Respiratory and Critical Care Medicine · 1996 · 1.4K citations

Asthma, Inflammatory Lung Disease, Advanced Lung Disease +16

Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats

Gloria De Carlo Massaro, Donald Massaro · Nature Medicine · 1997 · 529 citations

Inflammatory Lung Disease, Lung Inflammation, Physiology +7

Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in Vitro

Armin Hatzelmann, Christian Schudt · Journal of Pharmacology and Experimental Therapeutics · 2001 · 394 citations

Induction of a transient elevation in intracellular levels of adenosine-3',5'-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation.

L Simchowitz, Louis Fischbein, Isaias Spilberg et al. · The Journal of Immunology · 1980 · 217 citations · Full text

Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study

C.H. Compton, Jason Gubb, Richard Nieman et al. · The Lancet · 2001 · 210 citations

Translational Medicine, Selective Phosphodiesterase-4 Inhibitor, Medicine +5