The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells

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Yasuaki Itoh, Yuji Kawamata, Masataka Harada et al. · Nature · 2003 · 1.5K citations

Metabolic Syndrome, Insulin Signaling, Molecular Physiology +14

Oleic acid interacts with GPR40 to induce Ca²⁺signaling in rat islet β-cells: mediation by PLC and L-type Ca²⁺channel and link to insulin release

Ken Fujiwara, Fumihiko Maekawa, Toshihiko Yada · American Journal of Physiology-Endocrinology and Metabolism · 2005 · 250 citations

PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

Hyo-Sup Kim, You‐Cheol Hwang, Seung‐Hoi Koo et al. · PLoS ONE · 2013 · 105 citations · Full text

GPR40‐induced insulin secretion by the novel agonist TAK‐875: first clinical findings in patients with type 2 diabetes

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Randomized, Double-Blind, Dose-Ranging Study of TAK-875, a Novel GPR40 Agonist, in Japanese Patients With Inadequately Controlled Type 2 Diabetes

Kohei Kaku, Takahiro Araki, Ryoji Yoshinaka · Diabetes Care · 2012 · 95 citations · Full text