Concepedia

Glutathione S-transferase P1 (GSTP1) polymorphism in patients with chronic obstructive pulmonary disease

Takeo Ishii, Takeshi Matsuse, S Teramoto, H. Matsui, Mariko Miyao, Takayuki Hosoi, Hiroko Takahashi, Yoshinosuke Fukuchi, Yasuyoshi Ouchi

Thorax · 1999 · 186 citations · 21 references

DOIFull text

Open access

Abstract

Genetic polymorphism of exon 5 of GSTP1 may be associated with COPD because the GSTP1/Ile105 genotype is predominantly found in COPD. It is suggested that the GSTP1/Ile105 genotype may be less protective against xenobiotics in tobacco smoke.

References

21

The natural history of chronic airflow obstruction.

C. M. Fletcher, Richárd Pető · BMJ · 1977 · 2.4K citations · Full text

, , +16

Evidence-Based Health Policy—Lessons from the Global Burden of Disease Study

Christopher Murray, Alan D López · Science · 1996 · 2.2K citations

, , +23

Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force

NM Siafakas, P. Vermeire, N.B. Pride et al. · European Respiratory Journal · 1995 · 1.6K citations · Full text

, , +10

Free-radical chemistry of cigarette smoke and its toxicological implications.

D. F. CHURCH, W. A. PRYOR · Environmental Health Perspectives · 1985 · 1.4K citations · Full text

, , +13

Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution

Mary Ann Watson · Carcinogenesis · 1998 · 678 citations

, , +22