Synthesis and Antimicrobial Activities of Diphenyl(Arylamino)(1-Phenyl-3-(Pyridin-2-Yl)-1<i>H</i>-Pyrazol-4-Yl)Methylphosphonates

Abstract

A series of novel diphenyl (arylamino)(1-phenyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl)methylphosphonates have been synthesized in high yields. They were screened for their antibacterial activities against Escherichia coli (NCIM2065) as a Gram-negative bacterium, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram-positive bacteria and Schccaromycies cerevisiae as a fungus. The minimum inhibitory concentrations (MICs) of the synthetic compounds showed moderate antibacterial and antifungal activities at low concentrations (10–1000 μg/mL).