Diabetes mellitus suppresses hemodialysis-induced increases in tear fluid secretion

Abstract

BACKGROUND: Hemodialysis is essential for the survival of patients suffering from chronic renal failure. However, in diabetics the incidence of dry eye disease is higher than in non-diabetic individuals. Accordingly, we evaluated if this difference is attributable to different effects of hemodialysis on basal tear fluid secretion. METHODS: A modified Schirmer's eye test determined if hemodialysis improved basal tear secretion rates in 36 diabetic and non-diabetic patients undergoing hemodialysis. RESULTS: Basal tear secretion was invariant in diabetic patients whereas in non-diabetic individuals this process increased. CONCLUSION: In non-diabetic patients, autonomic neuropathy appears to be less severe and somewhat reversible since only in these individuals hemodialysis improved basal tear fluid secretion. This difference may be a factor contributing to the lower incidence of dry eye disease in non-diabetic patients.