Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres

A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid.

Yasuaki Ogawa, Masaki Yamamoto, Hiroaki Okada et al. · Chemical and Pharmaceutical Bulletin · 1988 · 502 citations · Full text

Engineering, Biomedical Engineering, Injectable Microcapsules +17

Solvent selection in the preparation of poly(dl-lactide) microspheres prepared by the solvent evaporation method

Roland Bodmeier, James W. McGinity · International Journal of Pharmaceutics · 1988 · 325 citations

Chemical Engineering, Engineering, Polymer Technology +9

Preparation of porous and nonporous biodegradable polymeric hollow microspheres

George Crotts, Tae Gwan Park · Journal of Controlled Release · 1995 · 249 citations

Engineering, Nanoporous Material, Polymer Science +3

Intracellular Distribution and Mechanism of Delivery of Oligonucleotides Mediated by Cationic Lipids

Olivier Zelphati, Francis C. Szoka · Pharmaceutical Research · 1996 · 229 citations

Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment

Rainer Alex, Roland Bodmeier · Journal of Microencapsulation · 1990 · 205 citations

Pharmaceutical Science, Engineering, Primary Emulsion +17