Concepedia

Tetramethylpyrazine Prevents Contrast-Induced Nephropathy by Inhibiting p38 MAPK and FoxO1 Signaling Pathways

Xuezhong Gong, Qian Wang, Xiaochun Tang, Yuerong Wang, Dan Fu, Huayi Lü, Guohua Wang, Svante Norgren

American Journal of Nephrology · 2013 · 42 citations · 23 references

DOI

Abstract

In summary, this study demonstrated the protective role of TMP against CIN and indicated the effects of TMP may be mediated by the inhibition of p38 MAPK and FoxO1 pathways. Thus, TMP may be a new potential therapeutic agent to prevent CIN.

References

23

Nitric oxide and prostanoids protect the renal outer medulla from radiocontrast toxicity in the rat.

Yoram Agmon, Hagit Peleg, Ziv Greenfeld et al. · Journal of Clinical Investigation · 1994 · 345 citations · Full text

, , +22

Urinary IL-18 and NGAL as Early Predictive Biomarkers in Contrast-Induced Nephropathy after Coronary Angiography

Ling Wang, Zhaohui Ni, Ben He et al. · Nephron Clinical Practice · 2008 · 267 citations

Some biomarkers of acute kidney injury are increased in pre-renal acute injury

Maryam Nejat, John W. Pickering, Prasad Devarajan et al. · Kidney International · 2012 · 198 citations · Full text

Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells

Xiao‐Nan Li, Yuanyuan Rong, Mei Zhang et al. · Biochemical and Biophysical Research Communications · 2009 · 130 citations · Full text

, , +14

In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis

Cristina Quintavalle, Monica Brenca, Francesca De Micco et al. · Cell Death and Disease · 2011 · 129 citations · Full text