The Role of the Spinal Opioid Receptor Like1 Receptor, the NK-1 Receptor, and Cyclooxygenase-2 in Maintaining Postoperative Pain in the Rat

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

Jean‐Claude Meunier, Catherine Mollereau, Lawrence Toll et al. · Nature · 1995 · 1.9K citations · Full text

Molecular Pharmacology, Endogenous Agonist, Functional Selectivity +8

Characterization of a rat model of incisional pain

Timothy J. Brennan, Erik Vandermeulen, Gerald F. Gebhart · Pain · 1996 · 1.1K citations

Health Sciences, Acute Pain, Pain Medicine +15

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

R. Michael Snider, Jay W. Constantine, John Lowe et al. · Science · 1991 · 864 citations

Potent Nonpeptide Antagonist, Biochemistry, Functional Selectivity +12

Physiological properties of unmyelinated fiber projection to the spinal cord

Lorne M. Mendell · Experimental Neurology · 1966 · 833 citations

Neurophysiology, Neuroanatomy, Spinal Biomechanics +9

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

Nobuko Futaki, Satoru Takahashi, Motofumi Yokoyama et al. · Prostaglandins · 1994 · 830 citations

Inflammation, Anti-inflammatory, Biochemistry +9