Concepedia

Fcγ Receptor Upregulation Is Associated With Immune Complex Inflammation in the Mouse Retina and Early Age-Related Macular Degeneration

Salome Murinello, Robert F. Mullins, Andrew Lotery, V. Hugh Perry, Jessica L. Teeling

Investigative Ophthalmology & Visual Science · 2013 · 49 citations · 44 references

DOIFull text

Open access

Abstract

Our studies suggest that immune complexes may contribute to AMD pathogenesis through interaction of IgG with FcγRs and might inform about possible adverse effects associated with therapeutic antibodies.

References

44

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

Maj-Linda B. Selenica, Milene L. Brownlow, Jeffy P. Jimenez et al. · Neurodegenerative Diseases · 2012 · 10.4K citations · Full text

Complement Factor H Polymorphism in Age-Related Macular Degeneration

Robert J. Klein, Caroline J. Zeiss, Emily Y. Chew et al. · Science · 2005 · 4.5K citations · Full text

Complement Factor H Polymorphism and Age-Related Macular Degeneration

Albert O. Edwards, Robert Ritter, Kenneth J. Abel et al. · Science · 2005 · 2.4K citations

Intravitreal Aflibercept (VEGF Trap-Eye) in Wet Age-related Macular Degeneration

Jeffrey S. Heier, David M. Brown, Victor Chong et al. · Ophthalmology · 2012 · 2.4K citations

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Microglial Physiology: Unique Stimuli, Specialized Responses

Richard M. Ransohoff, V. Hugh Perry · Annual Review of Immunology · 2009 · 1.8K citations

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