American Journal of Medical Genetics Part B Neuropsychiatric Genetics · 2003 · 33 citations · 28 references
Life SciencesGeneticsMolecular GeneticsHuman GeneticsNeurogeneticsPharmacogeneticsEtiology Of Mental DisordersNeuropsychiatric GeneticsPopulation PharmacogeneticsPsychiatric GeneticsPsychiatric PharmacogenomicsReceptor PolymorphismsEtiology Of Psychotic DisordersGenetic Risk VariantsPsychiatric Genetic RiskSerotonin Receptor PolymorphismsSerotonin ReceptorsSerotonin Transporter FunctionSerotonin Transporter Gene VariantsSerotonin Transporter Polymorphism
There is strong biological evidence relating alterations in the serotonergic system with mental disorders. These alterations may be originated at the DNA level by sequence mutations that alter the functioning of serotonin receptors and transporter. To test this hypothesis we investigated three genetic variants of the 5-HT2A receptor (-1438G/A, 102T/C and His452Tyr) and two variants of the serotonin transporter (a VNTR in the second intron and a 44 bp insertion/delition in the promoter region of the gene) in a clinical sample recruited in a human isolate and in surrounding areas in Northern Spain (N = 257) and in ethnically matched controls (N = 334). No clear association was found between 5-HT2A variants and psychosis. However, marginal associations were observed between the 5-HTT LPR and VNTR variants and psychosis (P < or = 0.05) indicating a minor contribution to psychosis of genetic alterations in this gene.
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Model-Free Analysis and Permutation Tests for Allelic Associations
Jing Hua Zhao, David Curtis, Pak C. Sham · Human Heredity · 1999 · 418 citations
Association between clozapine response and allelic variation in 5-HT2A receptor gene
M.J. Arranz, Dami A. Collier, Monsheel Sodhi et al. · The Lancet · 1995 · 329 citations
Medicine, Genetics, Pharmacology +16