Sulfoximines as Ligands in Copper-Catalyzed Asymmetric Vinylogous Mukaiyama-Type Aldol Reactions

Abstract

[reaction: see text] gamma,delta-Unsaturated alpha-hydroxy diesters with quaternary centers have been obtained with up to 99% ee in high yields using catalysts prepared from copper(II) triflate and C(1)-symmetric aminosulfoximines.