Labeling proteins on live mammalian cells using click chemistry

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless · Angewandte Chemie International Edition · 2001 · 12.9K citations

Combinatorial Chemistry, Click Chemistry Status, Engineering +17

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.4K citations

Terminal Alkynes, Chemical Engineering, Novel Organocatalysts +12

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless · Angewandte Chemie International Edition · 2001 · 9.3K citations · Full text

A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems

Nicholas J. Agard, Jennifer A. Prescher, Carolyn R. Bertozzi · Journal of the American Chemical Society · 2004 · 2.9K citations

Combinatorial Chemistry, Novel Organocatalysts, Bioorganic Chemistry +15

A general method for the covalent labeling of fusion proteins with small molecules in vivo

Antje Keppler, Susanne Gendreizig, Thomas Gronemeyer et al. · Nature Biotechnology · 2002 · 2K citations · Full text

Covalent Labeling, Immunocytochemical Technique, Protein Assembly +10