Proteasomal inhibition stabilizes topoisomerase IIα protein and reverses resistance to the topoisomerase II poison ethonafide (AMP-53, 6-ethoxyazonafide)

Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi

Javier Martı̂nez, Agnieszka Patkaniowska, Henning Urlaub et al. · Cell · 2002 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +6

A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription

Bong‐Gun Ju, Victoria V. Lunyak, Valentina Perissi et al. · Science · 2006 · 842 citations

Life Sciences, Biochemistry, Molecular Biology +17

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

Julian Adams, Mark L. Behnke, Shaowu Chen et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 683 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +12

Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.

William S. Dalton, Brian G.M. Durie, David S. Alberts et al. · PubMed · 1986 · 264 citations

Medicine, Oncology, Pharmacology +17

Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells

Terry H. Landowski, Nancy Olashaw, Deepak Agrawal et al. · Oncogene · 2003 · 185 citations

Medicine, Cancer Biology, Cell Adhesion +9