Concepedia

The Effect and Mechanism of Growth Hormone Replacement on Cognitive Function in Rats with Traumatic Brain Injury

Hao Zhang, Mengqi Han, Xiaonian Zhang, Xinting Sun, Feng Ling

PLoS ONE · 2014 · 43 citations · 41 references

DOIFull text

Open access

Abstract

rhGH treatment had a positive effect on cognitive function, which was more evident in GH-deficient rats. The increased expression of hippocampal and prefrontal BDNF and TrkB mRNA is implicated in rhGH therapy to improve cognitive function. Changes in the expression of hippocampal SYN mRNA following rhGH therapy may also play a role in improving cognitive function.

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