Concepedia

HDM2 Regulation by AURKA Promotes Cell Survival in Gastric Cancer

Vikas Sehdev, Ahmed Katsha, Janet Arras, Dunfa Peng, Mohammed Soutto, Jeffrey Ecsedy, Alexander Zaika, Abbes Belkhiri, Wael El‐Rifai

Clinical Cancer Research · 2013 · 65 citations · 35 references

DOIFull text

Open access

Abstract

Collectively, our novel findings indicate that AURKA promotes tumor growth and cell survival through regulation of HDM2-induced ubiquitination and inhibition of P53. Clin Cancer Res; 20(1); 76-86. ©2013 AACR.

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