Concepedia

IL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin

Norma Rallón, Vincent Soriano, Susanna Naggie, Clara Restrepo, David B. Goldstein, Eugenia Vispo, John G. McHutchison, José M. Benito

AIDS · 2011 · 45 citations · 28 references

DOIFull text

Open access

Abstract

IL28B CC genotype is a strong predictor of virological response to therapy in HIV/HCV-coinfected patients. This effect is mediated by an increase in viral clearance during the first 12 weeks of treatment and is mainly seen in patients infected with HCV genotypes 1 and 4.

References

28

Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice.

PubMed · 1997 · 7.1K citations

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

Dongliang Ge, Jacques Fellay, Alexander Thompson et al. · Nature · 2009 · 3.5K citations · Full text

, , +9

Diagnosis, management, and treatment of hepatitis C: An update # † ‡

Marc G. Ghany, Doris B. Strader, David L. Thomas et al. · Hepatology · 2008 · 3K citations · Full text

Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C

Laurent Castéra, Julien Vergniol, Juliette Foucher et al. · Gastroenterology · 2005 · 2.5K citations

, , +14

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

Yasuhito Tanaka, Nao Nishida, Masaya Sugiyama et al. · Nature Genetics · 2009 · 2.1K citations

, , +14