Abnormal dentate gyrus network circuitry in temporal lobe epilepsy

Abstract

Summary Patients with temporal lobe epilepsy exhibit developmental and acquired hippocampal abnormalities that include abnormally developed structure, neuron loss, aberrant neurogenesis, synaptic reorganization, granule cell dispersion, and gliosis. Determining which features play causal roles in epileptogenesis, and which features affect other aspects of the disorder, is a central challenge of epilepsy research. For an expanded treatment of this topic see Jasper’s Basic Mechanisms of the Epilepsies , Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado‐Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books ).