Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Amyloid β-peptide is produced by cultured cells during normal metabolism

Christian Haass, Michael G. Schlossmacher, Albert Y. Hung et al. · Nature · 1992 · 1.9K citations

Amyloid β-Peptide, Protein Expression, Biochemistry +11

Purification and cloning of amyloid precursor protein β-secretase from human brain

Sukanto Sinha, John P. Anderson, Robin Barbour et al. · Nature · 1999 · 1.6K citations

Neurodegenerative Diseases, Protein Secretion, Molecular Neuroscience +8

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck et al. · Nature · 1999 · 1.4K citations

Alzheimer's Disease, Biochemistry, Proteasome +3

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

Ishrut Hussain, David J. Powell, David Howlett et al. · Molecular and Cellular Neuroscience · 1999 · 1.1K citations

Proteomic Technology, Protein Secretion, Protein Function +7