Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NFκB pathway

Mechanism of activation of protein kinase B by insulin and IGF‐1.

Dario R. Alessi, Mirjana Andjelković, B. Caudwell et al. · The EMBO Journal · 1996 · 3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

Muneesh Tewari, Long T. Quan, Karen O’Rourke et al. · Cell · 1995 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

Scott H. Kaufmann, Serge Desnoyers, Yvonne Ottaviano et al. · PubMed · 1993 · 1.9K citations

Life Sciences, Biochemistry, Molecular Biology +14

Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)

Sanjaya Singh, Bharat B. Aggarwal · Journal of Biological Chemistry · 1995 · 1.4K citations · Full text

Life Sciences, Immunology, Pharmacology +12

Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.

Christian Jobin, Cynthia A. Bradham, Maria Pia Russo et al. · PubMed · 1999 · 720 citations

Life Sciences, Cell Biology, Immunology +17