Elevated Salt and Nitrate Levels in Drinking Water Cause an Increase of Blood Pressure in Schoolchildren

Abstract

<i>Aim:</i> To assess the influence on blood pressure in schoolchildren, of elevated sodium (Na<sup>+</sup>) and nitrate (NO<sup>–</sup><sub>3</sub>) levels in the drinking water. <i>Methods:</i> The blood pressure was recorded in three groups of age- and weight-matched schoolchildren (fourth and fifth graders) ingesting differing Na<sup>+</sup> and NO<sup>–</sup><sub>3</sub> concentrations with their drinking water. Group 1 (n = 452) imbibed high-Na<sup>+</sup>, high-NO<sup>–</sup><sub>3</sub> water (196 and 49 mg/l, respectively); group 2 (n = 418) consumed low-Na<sup>+</sup>, high-NO<sup>–</sup><sub>3</sub> water (25 and 49 mg/l, respectively) and group 3 (n = 86) drank low-Na<sup>+</sup>, low-NO<sup>–</sup><sub>3</sub> water (35 and 25 mg/l, respectively). The chloride (Cl<sup>–</sup>) concentrations varied in parallel to those of Na<sup>+</sup>. <i>Results:</i> Systolic blood pressure (SBP) and mean arterial pressure (MAP) were significantly increased in group 1 versus groups 2 and 3 (115.6 ± 12.2 and 86.4 ± 9.6 mm Hg vs. 111.1 ± 11.6 and 83 ± 8.3 and 107 ± 8.8 and 81 ± 7.2 mm Hg, respectively, p < 0.05). The SBP in group 2 was also significantly higher than in group 3 (111.1 ± 11.6 vs. 107 ± 8.8 mm Hg; p < 0.05). <i>Conclusions:</i> Elevated Na<sup>+</sup> (and possibly Cl<sup>–</sup>) in combination with high NO<sup>–</sup><sub>3</sub> concentrations in drinking water leads to an increase of SBP and MAP in fourth and fifth graders. The effects of Na<sup>+</sup> (and/or Cl<sup>–</sup>) and NO<sup>–</sup><sub>3</sub> on SBP and MAP appear to be additive, yet independent of each other.