Maintenance and consequences of membrane phospholipid asymmetry

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

Jasper Smit, Alfred H. Schinkel, Ronald P.J. Oude Elferink et al. · Cell · 1993 · 1.5K citations

Medicine, Molecular Genetics, Pharmacology +16

The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy

Arie J. Verkleij, R.F.A. Zwaal, B. Roelofsen et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1973 · 1.1K citations

Life Sciences, Biochemistry, Biophysics +17

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

Carlos Cordon‐Cardo, James P. O’Brien, João Paulo Boccia et al. · Journal of Histochemistry & Cytochemistry · 1990 · 1.1K citations

Medicine, Molecular Biology, Oncology +14

Inside-outside transitions of phospholipids in vesicle membranes

Harden M. McConnell, Roger D. Kornberg · Biochemistry · 1971 · 953 citations

Life Sciences, Biochemistry, Biophysics +14

Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes.

Teruhiro Utsugi, Alan J. Schroit, Jerome Connor et al. · PubMed · 1991 · 598 citations

Medicine, Immunology, Oncology +17