Toxicity and biodistribution of para-sulfonato-calix[4]arene in mice

Abstract

The acute in vivo toxicity of para-35S-sulfonato-calix[4]arene has been determined, with no toxicity for doses up to 100 mg kg−1. Biodistribution shows that the molecule is rapidly cleared in urine, that it does not accumulate in the liver and spleen, and is not observed in the brain.