Isomerès optiques du naftidrofuryl ( = 2‐[(naphth‐1‐yl)méthyl]‐3‐(tétrahydrofur‐2‐yl)propanoate de 2‐(diéthylamino) éthyle)

Abstract

Abstract Optical Isomers of Naftidrofuryl( = 2‐(Diethylamino)ethyl 2‐[(Naphth‐1‐yl)methyl]‐3‐(tetrahydrofur‐2‐yl)propanoate) The four optical isomers of naftidrofuryl ( 1 ) were prepared in two ways, by separation and resolution of the two diastereoisomeric racemates and by synthesis from the enantiomers of tetrahydrofuran‐2‐methanol ( 6 ); see Scheme }. The absolute configuration of one of the isomer as a tartrate monohydrate was established by X‐ray crystallography thus allowing the deduction of the absolute configurations of the other three optical isomers.