Capture and Release of Protein by a Reversible DNA‐Induced Sol–Gel Transition System

Abstract

Cross-links holding on, then letting go: Polyacrylamide main chains were branched with DNA strands, which could be gelatinized by DNA base pairing with a thrombin-bound cross-linking strand (see scheme). A complementary DNA strand can form a duplex with the cross-linking strand to dissolve the hydrogel and release the thrombin.