Archives of Dermatology · 1977 · 38 citations · 0 references
Life SciencesDermatologyImmunologyHistopathologyImmunogeneticsImmunopathologyHistocompatibilityHistocompatibility AntigensHla TypingHuman Leukocyte Antigen SystemImmunopathology Of SkinMajor Histocompatibility ComplexClass I Histocompatibility AntigensClass Ii Histocompatibility AntigensHla AllelesHla ImmunogeneticsHypertrophic Acne ScarsMolecular Hla TypingSerologic Hla TypingSerological Hla Typing
A number of different diseases have already been associated with various antigens of the HLA system.<sup>1,2</sup>The aim of the present report is to outline the possible associations between HLA histocompatibility antigens and patients with keloids and/or hypertrophic scars. Typing for 26 serologically detectable HLA antigens was performed in 40 patients and 131 healthy white controls. The diagnosis was based on clinical and histological criteria; patients with other concomitant diseases were excluded. The distribution of the HLA specificities that were tested is shown in the Table; the analysis of the relative risk factors and χ<sup>2</sup>values are also reported. Comparing the numbers individually, the antigens HLA-B14 (P < .02 after correction) and HLA-Bw16 (P not significant after correction) were observed more frequently than expected. While the frequency of HLA-B14 was 25% in patients instead of 3.8% in controls (relative risk = × 6.30), the frequency of HLA-Bw16 was 25%