A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys

Loss of bidirectional striatal synaptic plasticity in L-DOPA–induced dyskinesia

Barbara Picconi, Diego Centonze, Kerstin Håkansson et al. · Nature Neuroscience · 2003 · 816 citations

Life Sciences, Neurobiology, Neuroscience +14

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr et al. · Neuropharmacology · 1999 · 720 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease

Martin Lundblad, Malin Andersson, Christian Winkler et al. · European Journal of Neuroscience · 2002 · 665 citations · Full text

Medicine, Neuroscience, Pharmacology +15

Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat

CM Testa, A R Young, JB Penney · Journal of Neuroscience · 1994 · 511 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Relationship between the Appearance of Symptoms and the Level of Nigrostriatal Degeneration in a Progressive 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Macaque Model of Parkinson's Disease

Erwan Bézard, Sandra Doveró, Caroline Prunier et al. · Journal of Neuroscience · 2001 · 481 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17