The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

Rajesh K. Thimmulappa, Kim H., Sorachai Srisuma et al. · PubMed · 2002 · 1.2K citations

Life Sciences, Molecular Biology, Toxicology +17

An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen

Xiao-Dong Han, Yuet Wai Kan · Proceedings of the National Academy of Sciences · 2001 · 763 citations · Full text

Life Sciences, Pharmacology, Toxicology +17

Hepatocyte growth factor/ <i>c-met</i> signaling pathway is required for efficient liver regeneration and repair

Chang-Goo Huh, Valentina M. Factor, Aranzazu Sánchez et al. · Proceedings of the National Academy of Sciences · 2004 · 742 citations · Full text

Life Sciences, Cell Biology, Apoptosis +16

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

Ayako Enomoto · Toxicological Sciences · 2001 · 728 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

Nrf2 is essential for protection against acute pulmonary injury in mice

Yuet Wai Kan · Proceedings of the National Academy of Sciences · 1999 · 571 citations

Life Sciences, Molecular Biology, Molecular Genetics +17