Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Paola Scaffidi, Tom Misteli, Marco E. Bianchi · Nature · 2002 · 4.1K citations

Inflammation, Chromatin, Cytokine +10

The Danger Model: A Renewed Sense of Self

Polly Matzinger · Science · 2002 · 4.1K citations

Psychosocial Determinant, Humoral Response, Immunology +19

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Haichao Wang, Ona Bloom, Minghuang Zhang et al. · Science · 1999 · 3.4K citations

Shigella flexneri induces apoptosis in infected macrophages

Arturo Zychlinsky, M.C. Prévost, Philippe Sansonetti · Nature · 1992 · 1.2K citations

Inflammation, Infected Macrophages, Pathogenesis +4

Reversing established sepsis with antagonists of endogenous high-mobility group box 1

Huan Yang, Mahendar Ochani, Jianhua Li et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

Inflammation, Specific Inhibition, Cytokine +15