Detection of interferon in the sera of patients with psoriasis, and its enhancement by PUVA treatment

Abstract

Interferon-like activity could be detected in the sera of nineteen psoriatic patients (interferon titres between 8 and 64 i.u./ml), whereas healthy controls were negative. Following PUVA treatment the interferon levels increased significantly (interferon titres between 32 and 128 i.u./ml). An enhanced interferon production could explain some of the immunological phenomena connected with PUVA treatment.