Publication | Closed Access
Tandem Michael Addition/Ylide Epoxidation for the Synthesis of Highly Functionalized Cyclohexadiene Epoxide Derivatives
105
Citations
36
References
2008
Year
Chemical EngineeringEngineeringHeterocyclicAlkene MetathesisNatural SciencesDiversity-oriented SynthesisOrganic ChemistryCyclohexadiene Epoxide DerivativesCatalysisStereoselective SynthesisChemistryAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringChiral Sulfonium YlideGood Yields
A highly efficient diastereoselective synthesis of cyclohexadiene epoxide derivatives with a multi-stereocenter has been developed via a tandem ylide Michael addition/epoxidation. By employing a chiral sulfonium ylide, up to 96% ee can be achieved in good yields.
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