Journal of the American Chemical Society · 2008 · 105 citations · 36 references
Natural SciencesChemistryOrganic ChemistryDiversity-oriented SynthesisHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisAsymmetric Heterocycle SynthesisDiversity-oriented Stereoselective SynthesisEpoxidationEpoxide FormationStereospecific Reaction Design
A highly efficient diastereoselective synthesis of cyclohexadiene epoxide derivatives with a multi-stereocenter has been developed via a tandem ylide Michael addition/epoxidation. By employing a chiral sulfonium ylide, up to 96% ee can be achieved in good yields.
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