Postgraduate Medical Journal · 1993 · 97 citations · 19 references
MedicineGeriatric MedicineInternal MedicineGeriatric CareGeriatricsIron Metabolism DisordersIron Chelation TherapyIron DeficiencyIron Deficiency DisordersRestless Legs SyndromeSleep DisturbanceSleep Disturbances In Older AdultsFerritin StatusInsomnia SymptomsIron Deficiency AssessmentIron Deficiency DiagnosisIron Deficiency SymptomsRestless Legs Syndrome AssessmentRestless Legs Syndrome PathophysiologySerum Ferritin Assessment
The prevalence and significance of restless legs syndrome was assessed in 307 patients presenting to an acute-care geriatric medical service. Fifteen patients (5%) had restless legs syndrome; 13 (87%) of these patients had insomnia and 10 (67%) reported troublesome or frequent leg symptoms. Of 147 patients with current insomnia, iron deficiency (serum ferritin < 18 ng/ml) was present in 4/13 (31%) patients with restless legs and 8/134 (6%) patients without restless legs (P < 0.025). Improvement in symptoms of restless legs was noted with iron repletion. These findings suggest that restless legs syndrome is relatively common in the elderly and causes significant discomfort and sleep disturbance. Iron deficiency is a common and treatable cause.
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Diagnosis of iron-deficiency anemia in the elderly
Gordon Guyatt, Christopher Patterson, Mahmoud Ali et al. · The American Journal of Medicine · 1990 · 269 citations
Akathisia Variants and Tardive Dyskinesia
Thomas R. E. Barnes · Archives of General Psychiatry · 1985 · 259 citations
Medicine, Neurology, Psychiatry +12