Chiral Linker 1. A Novel Chiral Auxiliary Derived from m-Hydrobenzoin as Enantiomerically Pure Linker for Solid Phase Organic Chemistry

Abstract

The synthesis and utility of a novel, m-hydrobenzoin derived chiral auxiliary in stereoselective α- alkylation reactions using convenient solution chemistry as well as the attachment of an analogous system onto a solid support and its application as a dual chiral auxiliary and linker is described. Keywords: polymer support, chiral auxiliary, linker, enolate, alkylation, hydrobenzoin