A 3′‐untranslated region variant is associated with impaired expression of <i>CD226</i> in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus

Abstract

This study identified an association of CD226 with SLE in individuals of European ancestry. These data support the importance of the 3'-UTR SNP rs727088 in the regulation of CD226 transcription both in T cells and in NKT cells.