Quinone–carbohydrate nonglucoside conjugates as a new type of cytotoxic agents: Synthesis and determination of in vitro activity

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

K M Tewey, G L Chen, Eric M. Nelson et al. · Journal of Biological Chemistry · 1984 · 888 citations · Full text

Medicine, Oncology, Pharmacology +14

5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazolyl)-3-(4-sulfophenyl)tetrazolium, inner salt (MTS) and related analogs of 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) reducing to purple water-soluble formazans As cell-viability indicators

J. A. Barltrop, Terence C. Owen, Ann H. Cory et al. · Bioorganic & Medicinal Chemistry Letters · 1991 · 451 citations

Dentistry, Pharmacology, Drug Discovery +3

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.

D. Wolf, Varda Rotter · Proceedings of the National Academy of Sciences · 1985 · 414 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +11

Glucose conjugation for the specific targeting and treatment of cancer

Emilia Calvaresi, Paul J. Hergenrother · Chemical Science · 2013 · 382 citations · Full text

Life Sciences, Biochemistry, Oncology +14

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents

J. William Lown, Soo-Khoon Sim, Rwei-Ying Chang · Biochemical and Biophysical Research Communications · 1977 · 259 citations

Life Sciences, Biochemistry, Molecular Biology +12