Isoindoline-1,3-dione derivatives targeting cholinesterases: Design, synthesis and biological evaluation of potential anti-Alzheimer’s agents

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

Life Sciences, Biochemistry, Pharmacology +14

Atomic Structure of Acetylcholinesterase from <i>Torpedo californica</i> : A Prototypic Acetylcholine-Binding Protein

Joel L. Sussman, Michal Harel, Felix Frolow et al. · Science · 1991 · 2.7K citations

Life Sciences, Biochemistry, Molecular Biology +17

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

Jeffrey L. Cummings, Travis Morstorf, Kate Zhong · Alzheimer s Research & Therapy · 2014 · 1.7K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

David M. Bowen, Carolyn Beebe Smith, Pamela White et al. · Brain · 1976 · 1.3K citations

Life Sciences, Neurology, Neuroscience +7

High throughput artificial membrane permeability assay for blood–brain barrier

Li Di, Edward H. Kerns, Kristi Fan et al. · European Journal of Medicinal Chemistry · 2003 · 1.1K citations

Pharmacy, Biomedical Engineering, Neuroscience +11