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Novel renin inhibitors: synthesis of aminostatine and comparison with statine-containing analogues
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1986
Year
Statine CongenersMedicinal ChemistryCrystal StructureStatine-containing AnaloguesBiochemistryNovel Renin InhibitorsRenin InhibitorsMedicineNatural SciencesPharmacotherapyNon-peptide LigandDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryInhibitory ActivityDrug Discovery
The synthesis of renin inhibitors containing a novel amino-analogue of statine is described and inhibitory potencies are compared with those of statine congeners; the crystal structure of the aminostatine derivative (6) is reported.