Chemical and Pharmaceutical Bulletin · 1997 · 26 citations · 0 references
Life SciencesChemistryMedicinal ChemistryLipid BiochemistryOrganic ChemistryStructure-activity RelationshipsCholesterol MetabolismLipid ChemistryLipid MetabolismSterol MetabolismTriglyceride MetabolismActivity AnalysisHeteroaromatic CompoundsHigh-density Lipoprotein Cholesterol ModulationHigh-density Lipoprotein MetabolismMedicinal Chemistry Applications
A series of diesters of arylnaphthalene lignan and their heteroaromatic analogs were synthesized and evaluated for hypolipidemic activity. The disasters with modifications at C-3 showed excellent hypocholesterolemic and high-density lipoprotein (HDL) cholesterol-elevating activities. Structure-activity analysis indicated that the 2-pyridylmethyl ester 5l has the optimum activity.