Direct Block of Human Ether-a-go-go-Related Gene Potassium Channels by Caffeine

Adenosine 3‘,5‘-Phosphate in Biological Materials

R.W. Butcher, Earl W. Sutherland · Journal of Biological Chemistry · 1962 · 2.1K citations · Full text

Aldo-keto Reductase, Biological Materials, Chemical Biology +16

A structural basis for drug-induced long QT syndrome

John S. Mitcheson, Jun Chen, Monica Lin et al. · Proceedings of the National Academy of Sciences · 2000 · 929 citations · Full text

Cardiac Muscle, Channelopathies, Cardiomyopathy +11

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia.

Michael C. Sanguinetti, Mark Curran, Peter Spector et al. · Proceedings of the National Academy of Sciences · 1996 · 471 citations · Full text

Cardiac Muscle, Genetics, Sudden Death +20

Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by caffeine and related compounds

Éric Rousseau, Jeffrey K. Ladine, Qi-Yi Liu et al. · Archives of Biochemistry and Biophysics · 1988 · 343 citations

Muscle Function, Molecular Physiology, Physiological Research +12

Blocker protection in the pore of a voltage-gated K+ channel and its structural implications

Donato del Camino, Miguel Holmgren, Yi Liu et al. · Nature · 2000 · 339 citations

Electrical Engineering, Engineering, Voltage-gated K+ Channel +5