Concepedia

A New and Facile Synthesis of Quinazoline-2,4(1<i>H</i>,3<i>H</i>)-diones

Jiarong Li, Chen Xian, Daxin Shi, Ma Shuling, Qing Li, Qi Zhang, Tang Jianhong

Organic Letters · 2009 · 88 citations · 33 references

DOI

Abstract

A new and facile preparation of quinazoline-2,4(1H,3H)-diones was first reported which was the condensation of aromatic o-aminonitriles with DMF or N,N-diethylformamide in the presence of ZnCl(2) (0.5-10 mol %) at 190-200 degrees C in the sealed reactor.

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