AIDS · 2007 · 12 citations · 10 references
MedicineInfectious DiseasesPathologyHepatologyMolecular VirologyVirologyCirrhosisHepatic FibrosisHepatic PathologyLiver BiopsyLiver DiseaseViral HepatitisAminotransferase RatiosAspartate Aminotransferase ElevationBiomarkers Of SeverityHepatic Fibrosis BiomarkersLiver Disease Severity CriteriaLiver Fibrosis StagingSerum Aspartate AminotransferaseStaging Of Advanced Disease
Liver biopsy is currently the gold standard for determining the stage of liver fibrosis. There are risks associated with liver biopsy; therefore, surrogate markers to predict the severity of disease would be useful. We studied 50 patients with HIV/hepatitis C co-infection who had liver biopsies and determined that no patient with an aspartate aminotransferase/platelet ratio index (APRI) of 0.6 or less had stage F3 or F4 disease. The APRI is useful for excluding advanced disease in this patient population.
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