Analysis of hepatic metabolism affecting pharmacokinetics of propranolol in humans

A pharmacokinetic analysis program (multi) for microcomputer.

Kiyoshi Yamaoka, Yusuke Tanigawara, Terumichi Nakagawa et al. · Journal of Pharmacobio-Dynamics · 1981 · 2.5K citations · Full text

Pharmacokinetic Analysis Program, Nonlinear Curve Fitting, Pharmacokinetic Modeling +11

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

Y. Naritomi, Shigeyuki Terashita, Sumihisa Kimura et al. · PubMed · 2001 · 317 citations

Physiologically-based Pharmacokinetic Modeling, Cytochrome P450 Metabolism, Bioanalysis +21

Prediction of Pharmacokinetics Prior to In Vivo Studies. II. Generic Physiologically Based Pharmacokinetic Models of Drug Disposition

Patrick Poulin, Frank‐Peter Theil · Journal of Pharmaceutical Sciences · 2002 · 297 citations

Physiologically Based Pharmacokinetics, Pharmacokinetic Modeling, Pharmacodynamics +8

Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.

R S Obach · PubMed · 1997 · 281 citations

Pathology, Pharmacotherapy, Vitro Intrinsic Clearance +21