Partial molar volumes of isoniazid solutions in aqueous-ethanol mixtures at 298.15 K

Abstract

Densities (ρ) of antitubercular drug isoniazid solutions in water, aqueous-ethanol (20–80 vol % EtOH) and in pure ethanol at 298.15 K with different molar concentrations (0.01–0.16 mol dm−3) were measured. Experimental density data were used to calculate apparent molar volumes (φ v ) of isoniazid in different media. The φ v data were fitted to Massons relation and partial molar volumes (φ 0 ) of drug for infinitely dilute solution were determined for each solution. Experimental and derived properties were interpreted in terms of drug-solvent molecular interactions and structural fittings in studied systems.