Volumetric and Viscometric Studies of Antidepressant Drugs in Aqueous Medium at Different Temperatures

Abstract

Notriptyline hydrochloride and trimipramine maleate are used as antidepressants and analgesics. The density and viscosity of the aqueous solutions of these compounds are measured in a range of molality, m = (9.7·10−6 to 32.5·10−6) mol·g−1, at T = (293.15 to 313.15) K using a commercial densimeter and viscometer. The apparent molar volume (Vϕ), partial molar volume (Vm0), partial molar expansivity (E20), thermal expansion coefficient (α2), and Hepler's constant (∂2Vm0/∂T2) are calculated from the density data. The values of the B-coefficient and hydration number (Hn) are computed from the viscosity data.