Publication | Closed Access
Design and Synthesis of a Protein Catenane This work was supported by The Skaggs Institute for Chemical Biology, The Sloan Foundation, and NIH-GM570132 (PED). We thank Dr. Songpong Deechongkit for assistance with the analytical ultracentrifuge and CD measurements.
71
Citations
0
References
2001
Year
Bioorganic ChemistryProtein AssemblyBiomolecular Structure PredictionProtein CatenaneStructural BioinformaticsMolecular BiologyAnalytical UltracentrifugationChemical BiologyProtein FoldingProtein X-ray CrystallographyFolded ConformationSkaggs InstituteBiochemistryBioconjugationDna ReplicationConformational StudyNatural Product SynthesisCd MeasurementsStructural BiologyBio-orthogonal ChemistryNatural SciencesPeptide SynthesisP53 Protein CatenaneMedicineBackbone Structures
In contrast to DNA, proteins with topologically linked backbone structures have not yet been observed in Nature. We have chemically synthesized a p53 protein catenane (see schematic representation) consisting of interlocking cyclic polypeptides to demonstrate that such structures are synthetically attainable and can significantly stabilize the folded conformation of a protein. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2001/z16965_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.