Concepedia

Improving success rate of hydrogen-bond driven synthesis of co-crystals

Christer B. Aakeröy, J. Desper, Meg E. Fasulo

CrystEngComm · 2006 · 58 citations · 16 references

DOI

Concepts

Abstract

Increasing the negative charge of a hydrogen-bond acceptor using electron-donating substituents offers a significant improvement in hydrogen-bond driven synthesis of carboxylic acid⋯N-heterocycle co-crystals.

References

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Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?

�rn Almarsson, Michael J. Zaworotko · Chemical Communications · 2004 · 1.1K citations

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Building co-crystals with molecular sense and supramolecular sensibility

Christer B. Aakeröy, Debra J. Salmon · CrystEngComm · 2005 · 760 citations

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Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients

P. Vishweshwar, Jennifer A. McMahon, Matthew L. Peterson et al. · Chemical Communications · 2005 · 241 citations

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