FEMS Microbiology Letters · 1992 · 152 citations · 12 references
Life SciencesCell BiologyMicrobiologyCell AdhesionHost-pathogen InteractionsMucosal ImmunologyBacterial Virulence FactorsHost Cell AttachmentIntestinal Barrier FunctionLactic Acid BacteriaMucosal Barrier FunctionPathogen AdhesionAdhesion To Intestinal CellsAdhesion To Intestinal MucosaCell-cell Adhesion In PathogensConcentration-dependent BindingEscherichia ColiIntestinal Epithelial Barrier FunctionMicrobial Adhesion To MucosaSteric Constraints
Diarrheagenic Escherichia coli (ETEC) bearing CFA/I or CFA/II adhesive factors specifically adhere onto the brush border of the polarized epithelial human intestinal Caco-2 cells in culture. Heat-killed Lactobacillus acidophilus strain LB, that adheres onto Caco-2 cells, inhibits diarrheagenic Escherichia coli adhesion in a concentration-dependent manner. Since the L. acidophilus does not express ETEC-CFA adhesive factors, it can be postulated that the heat-killed L. acidophilus LB cells inhibit diarrheagenic E. coli attachment by steric hindrance of the human enterocytic ETEC receptors.
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