Concepedia

Fluorofenidone Attenuates Tubulointerstitial Fibrosis by Inhibiting TGF-β1-Induced Fibroblast Activation

Qiongjing Yuan, Rui Wang, Yu Peng, Xiao Fu, Wei Wang, Linghao Wang, Fangfang Zhang, Zhangzhe Peng, Gaoyun Hu, Zhaohe Wang,

American Journal of Nephrology · 2011 · 32 citations · 46 references

DOI

Abstract

AKF-PD treatment inhibits the progression of renal interstitial fibrosis in obstructed kidneys; this is potentially achieved by suppressing fibroblast activation. Therefore, AKF-PD is a special candidate for the treatment of renal fibrosis.

References

46

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Masayuki Iwano, David Plieth, Theodore M. Danoff et al. · Journal of Clinical Investigation · 2002 · 1.8K citations · Full text

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

Xiao Yang · The EMBO Journal · 1999 · 900 citations · Full text

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Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

Misako Sato, Yasuteru Muragaki, Shizuya Saika et al. · Journal of Clinical Investigation · 2003 · 744 citations · Full text

Predicting renal outcome in IgA nephropathy.

M. Gene Radford, James V. Donadío, Eric J. Bergstralh et al. · Journal of the American Society of Nephrology · 1997 · 440 citations

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Inhibition of Renal Fibrosis by Gene Transfer of Inducible Smad7 Using Ultrasound-Microbubble System in Rat UUO Model

Hui Y. Lan, Wei Mu, Naruya Tomita et al. · Journal of the American Society of Nephrology · 2003 · 340 citations