Publication | Open Access
HorC, a Hop-Resistance Related Protein, Presumably Functions in Homodimer Form
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2009
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Single Horc GeneHorc GenesSystems BiologyBioorganic ChemistryHomodimer FormProtein FunctionNatural SciencesProtein GeneticsDna ReplicationMolecular BiologySynthetic BiologyMolecular GeneticsMicrobiologyMolecular MicrobiologyChemical BiologyMedicineFused Horc GenesMolecular Diversity
To determine whether two HorC molecules coordinately form a single unit, the functional properties of covalently linked dimers of HorC encoded by tandemly fused horC genes were studied. Lactobacillus brevis introduced with the fused horC genes and a single horC gene exhibited same degree of resistance to hop compounds and cetyltrimethylammonium bromide. This suggests that HorC functions as a homodimer.
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