Increased degradation rates of protein in aging human fibroblasts and in cells treated with an amino acid analog

The limited in vitro lifetime of human diploid cell strains

Leonard Hayflick · Experimental Cell Research · 1965 · 5.8K citations

Life Sciences, Cell Biology, Genetics +9

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

Martin Gm, Sprague Ca, Epstein Cj · PubMed · 1970 · 1K citations

Life Sciences, Biology, Cell Biology +14

Altered Enzymes in Ageing Human Fibroblasts

R. Holliday, G. M. TARRANT · Nature · 1972 · 409 citations

Life Sciences, Biochemistry, Molecular Biology +14

Intracellular protein turnover

Food and Cosmetics Toxicology · 1976 · 201 citations

Protein Turnover in Mammalian Cell Cultures

Harry Eagle, Karl A. Piez, Ralph Fleischman et al. · Journal of Biological Chemistry · 1959 · 200 citations · Full text

Life Sciences, Biochemistry, Cell Biology +13