Effects of Organoantimony(III) Compounds of Sterically Hindered Bifunctional Tetradentate Ligands on the Reproductive System of Male Rats

Abstract

The antifertility activity of organoantimony(III) complexes PhSb[RC(NC 6 H 4 S)CH 2 (NC 6 H 4 S)CR′] {R′ = CH 3 (R 1 ) and R = R′ = CF 3 (R 2 )} derived from corresponding sterically hinlered bifuinctional tetradentate ligands in the male rats was determined. The administration of compounds R 1 and R 2 at the dose level of 20 mg/kg. b. wt. siignificantly reduced the weights of testes and epididymides. Auxiliary glands showed a significant reduction after the treatment of compound R 1 only. Treated animals showed a notable depression of spermatogenesis. The preleptotene spermatocytes were decreased by 76.19 and 47.06; the secondary spermatocytes by 87.4% and 54.87337; and the step‐19 spermatids by 72.9 and 46.77% respectively, following the compound R 1 and R 2 treatment. Reduced sperm count and motility resulted in 100% negative fertility in both the treated groups. A significant fall in the content of various biochemical parameters of eproductive tissues was observed after R 1 and R 2 treatment in comparison to controls.